Ann Griffith was born on Friday, 1 February 1754 in Richland, Bucks, Pennsylvania. She was the daughter of
Isaac Griffith and
Ann Burson. At the age of 18, Ann Griffith married
Aquila Price on Thursday, 27 February 1772 in Gunpowder, Baltimore, Maryland. At the age of 20, Ann Griffith married
William Matthews on Wednesday, 3 August 1774 in Gunpowder, Baltimore, Maryland. Ann Griffith died on Friday, 6 July 1792 at the age of 38 years, 5 months and 5 days.